- Additional processor and hard drive overhead will be required of the physical hardware, since both applications can be resource-intensive.
- From a security perspective, it's often preferable to separate mission-critical applications onto separate physical devices so that you can reduce the attack exposure on each machine. If your SQL Server is residing on your domain controller and an attacker were able to compromise the physical server using a SQL vulnerability, they would essentially have the "keys to the kingdom" since your sensitive AD information would also be compromised at that point.
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