This tip has two tips really:
By submitting your personal information, you agree that TechTarget and its partners may contact you regarding relevant content, products and special offers.
The first is an easier way of getting to the Task Manager. Use CTRL-SHIFT-ESC to get to it faster!
The second and main tip is this: Click the Processes tab. Search for NTVDM.exe and end that process. All 16-bit apps will be killed without rebooting.