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Disabling network scanning in most antivirus servers will improve sluggish internal networked applications. Antivirus servers are already protecting clients via the client interface. Having each system scan networked folders and connections for viruses is redundant.
I found this out the hard way when trying to run an application over the network. We were having speed issues with the application that the vendor attributed to "network" problems. We went so far as to have an outside consultant come in to troubleshoot the problem. As it turns out, we have Symantec Corporate antivirus on the network and it was set to scan networked drives. A simple setting change from the Symantec System Center Console changed all of the clients to not scan networked drives and the network problem went away immediately. Disabling this setting was not a security issue because each client was running antivirus as well as all of the servers.