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Automatically delete locally cached roaming profiles

How do I automatically delete locally cached roaming profiles? (We have limited drive space.) Also, is there a way to unconditionally delete a folder (i.e., a copy of a profile on local c: drive)? When I try to delete manually, it says "access denied" or "file may be in use."
To stop local caching of roaming profiles, edit the GPO and set the "Interactive Logon: Number of previous logons to cache" to 0. This is found in the Computer Configuration -> Windows Settings -> Security Settings -> Local Policies -> Security Options folder of a GPO.

To delete folders that claim "access denied," even when you are an administrator, first take ownership, then delete....

If the folder is open or in use, you will not be able to delete it.

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