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Lost ability to change security permissions on the server

I am running a Windows 2000 Server as a domain controller on a medium-sized network of Windows 2000 & XP clients. Everything has been running fine for a year or so, but now I can no longer change any security permissions on the server. If I attempt to change permissions, it comes back with an error saying that they can not be changed. I am using the administration account and have tried from multiple machines and the server with no luck. Any help would be greatly appreciated.
I've had the same problems on systems I've managed. I've resolved them sometimes by re-configuring DNS and other times by transferring the FSMO roles around to other domain controllers. You could attempt a forced replication of the domain. Check out the details in the following tips I wrote:
https://searchwindowsserver.techtarget.com/tip/Active-Directory-replication-failing-Check-the-topology
https://searchwindowsserver.techtarget.com/tip/Essential-tools-for-Active-Directory-replication
https://searchwindowsserver.techtarget.com/tip/Quick-Tips-Active-Directory-wont-replicate-to-domain-controllers
This was last published in January 2004

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